DC12: Redefining Human Energy and Metabolic Health
Pioneering Dodecanedioic Acid (DC12) and the Discovery of the 5th Macronutrient


A Seismic Shift in Improving Insulin Sensitivity and Metabolism
DC12 is not a protein, fat, carbohydrate or even an exogenous ketone. Rather DC12 is a 5th macronutrient and an entirely unique "clean" energy substrate that provides their same metabolic benefits (energy) but prevent their metabolic pitfalls (increased body weight and/or hyperglycemia).
Addressing the Growing Metabolic Health Crisis
The Broken Promise of Traditional Energy
For many years, we have been misinformed and inadequately educated about nutrition and energy. This has led to an increase in sugar, carbohydrates, unhealthy fats, caffeine, and other harmful additives in our diets, which are fueling a long-term rise in chronic metabolic conditions such as high blood sugar, insulin resistance, type 2 diabetes, obesity, high blood pressure, cardiovascular disease, and more.


Clean Energy That Supports Metabolic Flexibility
Key amongst it's many benefits, DC12 helps the body switch from burning carbohydrates to burning fat. This is known as metabolic flexibility, and it makes DC12 extraordinarily unique because only actual ketosis has been known to do that. Ketones like beta-hydroxybutyrate (BHB) or acetoacetate do not burn fatty acids – only dietary ketosis does. And most people cannot maintain dietary ketosis; so, DC12 is an excellent next step in weight management after a weight-bearing exercise regimen and good nutrition.
And unlike glucose, DC12 supports normal insulin sensitivity and blood sugar levels. These characteristics are crucial to maintaining a healthy metabolism and weight.
Essential Facts About DiCarbs and DC12

Natural Source Of "Clean" Energy
DiCarbs are known to be a good source of energy with physical-chemical characteristics intermediate between carbohydrates and fatty acids. They are oxidized like fatty acids but, like glucose, their salts are soluble in water. Their end product of oxidation, succinic acid, provides an indispensable substrate for glucose metabolism.

Supports Insulin Sensitivity
DiCarbs do not require insulin, nor do they stimulate insulin secretion, while increasing fatty acid oxidation, therefore they are a useful energy substrate for obese and diabetic subjects. In fact, insulin is a hormone which stimulates fat accumulation and therefore promotes obesity.

Bioavailability
DC12 is water soluble and good at being used by both mitochondria and peroxisomes in the liver and kidney. A recent study found that DC12 avoids first pass liver metabolism so it can be quickly consumed as energy, and was utilized by many tissues - with DC12-specific breakdown products in the liver, kidney, muscle, heart and brain.

7.2 Calories - Nearly 2x Energy of Carbs
Carbohydrates provide 4 calories per gram while fat provides 9 calories per gram. DC12 provides 7.2 calories per gram (Mingrone et al., 2006; NutrRev 64:449-56) without increasing fat mass as do fatty acids.

Fat Burn, Weight Loss & T2D Control
DiCarbs not only provide energy to the body but also improve insulin resistance and glucose utilization in diabetic patients. Therefore, DiCarbs support weight loss and improves type 2 diabetes control. Given the high-caloric, low-fat characteristics of DiCarbs, they have been shown to be a strong energy substrate during exercise, reducing muscle fatigue and increasing muscle strength (Salinari et al., 2006; Am J Physiol Endocrinol Metab ;291:E1051-8).DiCarbs

Exercise Performance & Hydration
DC12 is a source of fuel during exercise and helps preserve muscle glycogen stores. This is crucial to anyone interested in being their best during while exercising for extended periods of time. DC12 provides fuel to muscle immediately, without the limitations that medium and long chain fats have.
Our Mission: Discover a Superior Energy Source with Profound Metabolic Benefits and No Metabolic Pitfalls
Jemyll’s research on dicarboxylic acids started with the objective of helping people with metabolic disorders utilize nutrients other than fatty acids or glucose, since they’re unable to process them properly.
Dating back to the 1990s, there have been over 40 compelling animal and human studies about DC12 and DiCarbs published.
New Research
Dicarboxylic Acids Counteract The Metabolic Effects Of A Western Diet By Boosting Energy Expenditure
Lidia Castagneto-Gissey, Stefan R. Bornstein,and Geltrude Mingrone
Journal of Clinical Investigation, 2024
Dodecanedioic acid prevents and reverses metabolic-associated liver disease and obesity and ameliorates liver fibrosis in a rodent model of diet-induced obesity
Giulia Angelini, Sara Russo, Fabrizia Carli, Patrizia Infelise, Simona Panunzi, Alessandro Bertuzzi, Maria Emiliana Caristo, Erminia Lembo, Roberta Calce, Stefan R. Bornstein, Amalia Gastaldelli, Geltrude Mingrone
The FASEB Journal, 2024
Significant Real World Applications

Exercise Advocate
Looking for sustained energy and hydration during workouts, knowledgeable about nutrition and avoids quick fixes and crash-inducing supplements

Weight Manager
Knows that they need to get their weight under control and actively seeking healthy, natural solutions vs. fad diets, meal replacements and pharmaceutical options

Type 2 Diabetes Controller
Living with T2D, understands the importance and roles of insulin and glucose monitoring, and needs to make sure what they ingest is backed by clear, proven science

Wellness & Longevity Optimizer
Invested in their overall health and well being. Frequent consumers of health-related media, reads all the nutrition information labels, actively monitors their diets and advocates to others
What The Experts Are Saying About DC12

Dr. José-Manuel Fernández-Real
Dean, School of Medicine
University of Girona

"From obesity to liver disease to cognitive health, Metabolyte offers a unique metabolic advantage—delivering energy in a sustained, insulin-independent manner while activating key longevity pathways. This is the future of precision nutrition."

Dr. Geltrude Mingrone
Professor of Diabetes and Metabolic Disease at King’s College of Rome, and Director of the Centre for Obesity related pathologies at the Catholic University of Rome
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