DC12 Research Library
DC12 and DiCarbs have shown in human and animal studies to improve energy, metabolism and weight management
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Building On Decades Of Research, New Studies Provide Compelling Evidence Of DC12’s Impact On Metabolic Health
Spotlight Study #1
Dicarboxylic Acids Counteract The Metabolic Effects Of A Western Diet By Boosting Energy Expenditure
Lidia Castagneto-Gissey, Stefan R. Bornstein,and Geltrude Mingrone
Includes findings about DC12's ability to address:
- Insulin resistance and energy expenditure
- The negative effects of a high-fat diet
- Weight gain
- Reducing the effects of dietary triglycerides
Spotlight Study #2
Dodecanedioic acid prevents and reverses metabolic-associated liver disease and obesity and ameliorates liver fibrosis in a rodent model of diet-induced obesity
Giulia Angelini, Sara Russo, Fabrizia Carli, Patrizia Infelise, Simona Panunzi, Alessandro Bertuzzi, Maria Emiliana Caristo, Erminia Lembo, Roberta Calce, Stefan R. Bornstein, Amalia Gastaldelli, Geltrude Mingrone
The FASEB Journal. 2024 Nov 30;38(22):e70202.
Includes findings about:
The possible role of DC12 as a therapeutic option for the prevention and treatment of MASH.
Full Clinical Research Library
Dicarboxlic Acids Counteract The Metabolic Effects Of A Western Diet By Boosting Energy Expenditure
Dodecanedioic acid prevents and reverses metabolic-associated liver disease and obesity and ameliorates liver fibrosis in a rodent model of diet-induced obesity
Giulia Angelini, Sara Russo, Fabrizia Carli, Patrizia Infelise, Simona Panunzi, Alessandro Bertuzzi, Maria Emiliana Caristo, Erminia Lembo, Roberta Calce, Stefan R. Bornstein, Amalia Gastaldelli, Geltrude Mingrone
Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity
Eric S. Goetzman, ... , Steven F. Dobrowolski, Birgit Schilling
Journal of Clinical Investigation, 2024
Use of dicarboxylic acids in type 2 diabetes
Geltrude Mingrone, Lidia Castagneto-Gissey & Katherine Macé
British Journal of Clinical Pharmacology, 2012
Six weeks’ sebacic acid supplementation improves fasting plasma glucose, HbA1c and glucose tolerance in db/db mice
Diabetes, Obesity and Metabolism, 2010
Effect of Oral Sebacic Acid on Postprandial Glycemia, Insulinemia, and Glucose Rate of Appearance in Type 2 Diabetes
A Iaconelli, A Gastaldelli, C Chiellini, D Gniuli, A Favuzzi, C Binnert, K Mace, G Mingrone
Diabetes Care, 2010
Medium-Chain, Even-Numbered Dicarboxylic Acids as Novel Energy Substrates: An Update
Geltrude Mingrone, MD, PhD, and Marco Castagneto, MD
Nutrition Reviews, Vol. 64, No. 10, 2006
Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetic subjects
S Salinari, A Bertuzzi, A Gandolfi, AV Greco, A Scarfone, M Manco, G Mingrone
Am J Physiol Endocrinol Metab 291, 2006
Approximate linear confidence and curvature of a kinetic model of dodecanedioic acid in humans
Simona Panunzi, Andrea De Gaetano, and Geltrude Mingrone
Am J Physiol Endocrinol Metab 289, 2005
Oxidation of D-[U ±14C] Glucose and [1,12 ±14C] Dodecanedioic Acidby Pancreatic Islets from Goto-Kakizaki Rats
W. J. Malaisse, M. Doherty, L. Ladriere, A. V. Greco, G. Mingrone
Horm Metab Res 2001
Oxidation of [l,12-14C]dodecanedioic acid by rat pancreatic islets
Willy J Malaisse, Aldo V. Greco And Geltrude Mingrone
International Journal Of Molecular Medicine 6: 453-454, 2000
Pharmacokinetics of sebacic acid in rats
AM Favuzzi, G Mingrone, A Bertuzzi, S Salinari, A Gandolfi, AV Greco
European Review for Medical and Pharmacological Sciences , 1999
Disposition of Dodecanedioic Acid in Humans
Bertuzzi A, Mingrone G, Gandolfi A, Greco AV, Salinari S
The Journal of Pharmacology and Experimental Therapeutics 292, 1999
A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples
E Capristo, G Mingrone, A De Gaetano, G Addolorato, AV Greco, G Gasbarrini
Clinica Chimica Acta 289, 1999
Comparison Between Dodecanedioic Acid and Long-Chain Triglycerides as an Energy Source in Liquid Formula Diets
G Mingrone, A De Gaetano, AV Greco, E Capristo, G Benedetti, M Castagneto, G Gasbarrini
Journal of Parenteral And External Nutrition, 1999
The Metabolic Effect of Dodecanedioic Acid Infusion in Non–Insulin-Dependent Diabetic Patients
Aldo V Greco MD A, Geltrude Mingrone MD, PhD A, Esmeralda Capristo MD A, Giuseppe Benedetti MD A, Andrea De Gaetano MD, PhD B, Giovanni Gasbarrini MD A
Applied Nutritional Investigation Vol 14, 1999
Dodecanedioic acid infusion induces a sparing effect on whole-body glucose uptake, mainly in non-insulin-dependent diabetes mellitus
G Mingrone, A De Gaetano, AV Greco, E Capristo, G Benedetti, M Castagneto, G Gasbarrini
British Journal of Nutrition, 78, 1997
Kinetics of dodecanedioic acid and effect of its administration on glucose kinetics in rats
A Bertuzzi, G Mingrone, A De Gaetano, A Gandolfi, AV Greco, S Salinari
British Journal of Nutrition, 78, 1997
Uptake of dodecanedioic acid by isolated rat liver
AN Grecoa, G Mingronea, A De Gaetano, L Amigo, L Puglielli, M Castagneto, F Nervi
Clinica Chimica Acta, 258, 1997
Plasma Clearance and Oxidation of Dodecanedioic Acid in Humans
G Mingrone, A De Gaetano, AV Greco, G Benedetti, E Capristo, M Castagneto, G Gasbarrini
Journal of Parenteral and Enteral Nutrition, Vol 20, 1996
Pharmacokinetic Analysis of Dodecanedioic Acid in Humans From Bolus Data
A Bertuzzi, G Mingrone, A Gandolfi, AV Greco, S Salinari
Journal of Parenteral and Enteral Nutrition, Vol 19, 1995
Dicarboxylic acids, an alternate fuel substrate in parenteral nutrition: an update
A.V. Grego and G. Mingrone
Clinical Nutrition, 14, 1995
Pharmacokinetic Profile of Dodecanedioic Acid, a Proposed Alternative Fuel Substrate
G Mingrone, AV Greco, A De Gaetano, A Tataranni, C Raguso, M Castagneto
Journal of Parenteral and Enteral Nutrition, 18, 1994
Dicarboxylic Acids and Glucose Utilization in Humans: Effect of Sebacate
CA Raguso, G Mingrone, AV Greco, PA Tataranni, A De Gaetano, M Castagneto
Journal of Parenteral and Enteral Nutrition, 18, 1994
Kinetics and Thermogenesis of Medium-Chain Monocarboxylic and Dicarboxylic Acids in Man: Sebacate and Medium-Chain Triglycerides
G Mingrone, AV Greco, M Castagneto, A De Gaetano, PA Tataranni, C Raguso
Journal of Parenteral and Enteral Nutrition, 17, 1993
Sebacic Acid Binding To Human Plasma Albumin
A Bertuzzi, E Finotti, G Mingrone, AV Greco
Biochemical Pharmacology, Vol.45, 1993
Use of Even-Numbered Carbon Atom Dicarboxylic Salts in Parenteral Nutrition as Fuel Substrate
G Mingrone, RM Tacchino, M Castagneto, E Finotti, AV Greco
Journal of Parenteral and Enteral Nutrition, 16, 1992
Metabolic Effects and Disposition of Sebacate, an Alternate Dicarboxylic Fuel Substrate
Aldo Virgilio Greco; Geltrude Mingrone; Comasia Raguso; Antonio Tataranni; Enrico Finotti; Roberto M. Tacchino; Esmeralda Capristo; Andrea De Gaetano; Marco Castagneto
Ann Nutr Metab , 36, 1992
Tracer Study of Metabolism and Tissue Distribution of Sebacic Acid in Rats
A Tataranni, G Mingrone, A De Gaetano, C Raguso, V Greco
Ann Nutr Metab , 36, 1992
Tissue Uptake and Oxidation of Disodium Sebacate in Man
G. Mingrone, A.V. Greco, A. Bertuzzi, E. Arcieri-Mastromattei, R.M. Tacchino, F. Marino, E. Finotti, M. Castagneto
Journal of Parenteral and Enteral Nutrition, 15, 1991
Pharmacokinetic Analysis of Azelaic Acid Disodium Salt A Proposed Substrate for Total Parenteral Nutrition
A Bertuzzi, A Gandolfi, S Salinari, G Mingrone, E Arcieri-Mastromattei, E Finotti, AV Greco
Clin. Pharmacokinet, 20, 1991
Short-Term Infusion of Azelaic Acid us Intralipid in Healthy Subjects Evaluated by Indirect Calorimetry
RM Tacchino, G Mingrone, F Marino, E Arcieri‐Mastromattei, AV Greco, M Castagneto
Journal of Parenteral and Enteral Nutrition, 14, 1990
Preliminary Studies of a Dicarboxylic Acid as an Energy Substrate in Man
Journal of Parenteral and Enteral Nutrition, 13, 1989
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