DC12 Research Library

DC12 and DiCarbs have shown in human and animal studies to improve energy, metabolism and weight management

20 +
Years of Clinical Development
30 +
Published Studies
4
Human Trials
10
In-Market Customers
Geltrude Speaking v1

Spotlight Study #1

Dicarboxylic Acids Counteract The Metabolic Effects Of A Western Diet By Boosting Energy Expenditure

Lidia Castagneto-Gissey, Stefan R. Bornstein,and Geltrude Mingrone

The Journal of Clinical Investigation. 2024 Jun 6;134(12).
 

Includes findings about DC12's ability to address:

  • Insulin resistance and energy expenditure
  • The negative effects of a high-fat diet
  • Weight gain
  • Reducing the effects of dietary triglycerides

Spotlight Study #2

Dodecanedioic acid prevents and reverses metabolic-associated liver disease and obesity and ameliorates liver fibrosis in a rodent model of diet-induced obesity

Giulia Angelini, Sara Russo, Fabrizia Carli, Patrizia Infelise, Simona Panunzi, Alessandro Bertuzzi, Maria Emiliana Caristo, Erminia Lembo, Roberta Calce, Stefan R. Bornstein, Amalia Gastaldelli, Geltrude Mingrone

The FASEB Journal. 2024 Nov 30;38(22):e70202.

Includes findings about:

DC12’s ability to protect against and/or reverse metabolic dysfunction-associated steatohepatitis (MASH)  

The possible role of DC12 as a therapeutic option for the prevention and treatment of MASH.

Full Clinical Research Library

2024
Dicarboxlic Acids Counteract The Metabolic Effects Of A Western Diet By Boosting Energy Expenditure
 
Lidia Castagneto-Gissey, Stefan R Bornstein, and Geltrude Mingrone
 
Journal of Clinical Investigation, 2024
 
2024
Dodecanedioic acid prevents and reverses metabolic-associated liver disease and obesity and ameliorates liver fibrosis in a rodent model of diet-induced obesity
 

Giulia Angelini, Sara Russo, Fabrizia Carli, Patrizia Infelise, Simona Panunzi, Alessandro Bertuzzi, Maria Emiliana Caristo, Erminia Lembo, Roberta Calce, Stefan R. Bornstein, Amalia Gastaldelli, Geltrude Mingrone

The FASEB Journal, 2024
 
2024
Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity

Eric S. Goetzman, ... , Steven F. Dobrowolski, Birgit Schilling

Journal of Clinical Investigation, 2024

2012
Use of dicarboxylic acids in type 2 diabetes

Geltrude Mingrone, Lidia Castagneto-Gissey & Katherine Macé

British Journal of Clinical Pharmacology, 2012

2010
Six weeks’ sebacic acid supplementation improves fasting plasma glucose, HbA1c and glucose tolerance in db/db mice
 
Membrez, C. J. Chou, F. Raymond, R. Mansourian, M. Moser, I. Monnard, C. Ammon-Zufferey, K. Mace, G. Mingrone, C. Binnert

Diabetes, Obesity and Metabolism, 2010

2010
Effect of Oral Sebacic Acid on Postprandial Glycemia, Insulinemia, and Glucose Rate of Appearance in Type 2 Diabetes

A Iaconelli, A Gastaldelli, C Chiellini, D Gniuli, A Favuzzi, C Binnert, K Mace, G Mingrone

Diabetes Care, 2010

2006
Medium-Chain, Even-Numbered Dicarboxylic Acids as Novel Energy Substrates: An Update

Geltrude Mingrone, MD, PhD, and Marco Castagneto, MD 

Nutrition Reviews, Vol. 64, No. 10, 2006

2006
Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetic subjects

S Salinari, A Bertuzzi, A Gandolfi, AV Greco, A Scarfone, M Manco, G Mingrone

Am J Physiol Endocrinol Metab 291, 2006

2005
Approximate linear confidence and curvature of a kinetic model of dodecanedioic acid in humans

Simona Panunzi, Andrea De Gaetano, and Geltrude Mingrone

Am J Physiol Endocrinol Metab 289, 2005

2001
Oxidation of D-[U ±14C] Glucose and [1,12 ±14C] Dodecanedioic Acidby Pancreatic Islets from Goto-Kakizaki Rats

W. J. Malaisse, M. Doherty, L. Ladriere, A. V. Greco, G. Mingrone

Horm Metab Res 2001

2000
Oxidation of [l,12-14C]dodecanedioic acid by rat pancreatic islets

Willy J Malaisse, Aldo V. Greco And Geltrude Mingrone

International Journal Of Molecular Medicine 6: 453-454, 2000

 

1999
Pharmacokinetics of sebacic acid in rats

AM Favuzzi, G Mingrone, A Bertuzzi, S Salinari, A Gandolfi, AV Greco

European Review for Medical and Pharmacological Sciences , 1999

 

1999
Disposition of Dodecanedioic Acid in Humans

Bertuzzi A, Mingrone G, Gandolfi A, Greco AV, Salinari S

The Journal of Pharmacology and Experimental Therapeutics 292, 1999

 

1999
A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples

E Capristo, G Mingrone, A De Gaetano, G Addolorato, AV Greco, G Gasbarrini

Clinica Chimica Acta 289, 1999

1999
Comparison Between Dodecanedioic Acid and Long-Chain Triglycerides as an Energy Source in Liquid Formula Diets

G Mingrone, A De Gaetano, AV Greco, E Capristo, G Benedetti, M Castagneto, G Gasbarrini

Journal of Parenteral And External Nutrition, 1999

 

1998
The Metabolic Effect of Dodecanedioic Acid Infusion in Non–Insulin-Dependent Diabetic Patients

Aldo V Greco MD A, Geltrude Mingrone MD, PhD A, Esmeralda Capristo MD A, Giuseppe Benedetti MD A, Andrea De Gaetano MD, PhD B, Giovanni Gasbarrini MD A

Applied Nutritional Investigation Vol 14, 1999

 

1997
Dodecanedioic acid infusion induces a sparing effect on whole-body glucose uptake, mainly in non-insulin-dependent diabetes mellitus

G Mingrone, A De Gaetano, AV Greco, E Capristo, G Benedetti, M Castagneto, G Gasbarrini

British Journal of Nutrition, 78, 1997

 

1997
Kinetics of dodecanedioic acid and effect of its administration on glucose kinetics in rats

A Bertuzzi, G Mingrone, A De Gaetano, A Gandolfi, AV Greco, S Salinari

British Journal of Nutrition, 78, 1997

 

1997
Uptake of dodecanedioic acid by isolated rat liver

AN Grecoa, G Mingronea, A De Gaetano, L Amigo, L Puglielli, M Castagneto, F Nervi

Clinica Chimica Acta, 258, 1997

 

1996
Plasma Clearance and Oxidation of Dodecanedioic Acid in Humans

G Mingrone, A De Gaetano, AV Greco, G Benedetti, E Capristo, M Castagneto, G Gasbarrini

Journal of Parenteral and Enteral Nutrition,  Vol 20, 1996

 

1995
Pharmacokinetic Analysis of Dodecanedioic Acid in Humans From Bolus Data

A Bertuzzi, G Mingrone, A Gandolfi, AV Greco, S Salinari

Journal of Parenteral and Enteral Nutrition,  Vol 19, 1995

 

1995
Dicarboxylic acids, an alternate fuel substrate in parenteral nutrition: an update

A.V. Grego and G. Mingrone 

Clinical Nutrition, 14, 1995

 

1994
Pharmacokinetic Profile of Dodecanedioic Acid, a Proposed Alternative Fuel Substrate

G Mingrone, AV Greco, A De Gaetano, A Tataranni, C Raguso, M Castagneto

Journal of Parenteral and Enteral Nutrition, 18, 1994

 

1994
Dicarboxylic Acids and Glucose Utilization in Humans: Effect of Sebacate

CA Raguso, G Mingrone, AV Greco, PA Tataranni, A De Gaetano, M Castagneto

Journal of Parenteral and Enteral Nutrition, 18, 1994

 

1993
Kinetics and Thermogenesis of Medium-Chain Monocarboxylic and Dicarboxylic Acids in Man: Sebacate and Medium-Chain Triglycerides

G Mingrone, AV Greco, M Castagneto, A De Gaetano, PA Tataranni, C Raguso

Journal of Parenteral and Enteral Nutrition, 17, 1993

 

1993
Sebacic Acid Binding To Human Plasma Albumin

A Bertuzzi, E Finotti, G Mingrone, AV Greco

Biochemical Pharmacology, Vol.45, 1993

 

1992
Use of Even-Numbered Carbon Atom Dicarboxylic Salts in Parenteral Nutrition as Fuel Substrate

G Mingrone, RM Tacchino, M Castagneto, E Finotti, AV Greco

Journal of Parenteral and Enteral Nutrition, 16, 1992

 

1992
Metabolic Effects and Disposition of Sebacate, an Alternate Dicarboxylic Fuel Substrate

Aldo Virgilio Greco; Geltrude Mingrone; Comasia Raguso; Antonio Tataranni; Enrico Finotti; Roberto M. Tacchino; Esmeralda Capristo; Andrea De Gaetano; Marco Castagneto

Ann Nutr Metab , 36, 1992

 

1992
Tracer Study of Metabolism and Tissue Distribution of Sebacic Acid in Rats

A Tataranni, G MingroneA De Gaetano, C Raguso, V Greco

Ann Nutr Metab , 36, 1992

 

1991
Tissue Uptake and Oxidation of Disodium Sebacate in Man

G. Mingrone, A.V. Greco, A. Bertuzzi, E. Arcieri-Mastromattei, R.M. Tacchino, F. Marino, E. Finotti, M. Castagneto

Journal of Parenteral and Enteral Nutrition, 15, 1991

 

1991
Pharmacokinetic Analysis of Azelaic Acid Disodium Salt A Proposed Substrate for Total Parenteral Nutrition

A Bertuzzi, A Gandolfi, S Salinari, G Mingrone, E Arcieri-Mastromattei, E Finotti, AV Greco

Clin. Pharmacokinet, 20, 1991

 

1990
Short-Term Infusion of Azelaic Acid us Intralipid in Healthy Subjects Evaluated by Indirect Calorimetry

RM Tacchino, G Mingrone, F Marino, E Arcieri‐Mastromattei, AV Greco, M Castagneto

Journal of Parenteral and Enteral Nutrition, 14, 1990

 

1989
Preliminary Studies of a Dicarboxylic Acid as an Energy Substrate in Man
Mingrone, R.M. Tacchino, A.V. Greco, E. Arcieri-Mastromattei, F. Marino, E. Finotti, E. Castagneto

Journal of Parenteral and Enteral Nutrition, 13, 1989

 

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